KissPeptin-10Kisspetin

Kisspeptin-10: Overview, Research Uses & Key Information

Kisspeptin-10, also known as KP-10, is the smallest fully bio active fragment of the kisspeptin peptide family.

It originates from the KISS1 gene.

This decapeptide consists of the amino acid sequence Tyr‑Asn‑Trp‑Asn‑Ser‑Phe‑Gly‑Leu‑Arg‑Phe‑NH₂.

Key Biological Roles

Reproductive Hormone Activation
Kisspeptin‑10 binds with high affinity to the G‑protein‑coupled receptor GPR54 (also known as KISS1R), stimulating the release of GnRH (gonadotropins-releasing hormone), which in turn drives the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—critical for puberty and fertility

Tumor Suppression
Originally discovered as part of the KISS1 metastasis-suppressor gene, kisspeptin‑10 acts as an inhibitor of tumor spread in cancers such as melanoma and breast cancer

Cardiovascular Effects
However, it acts as a potent vasoconstrictor and inhibits angiogenesis.

Consequently, in heart tissue, Kisspeptin‑10 promotes collagen deposition, influencing cardiac fibroblasts through focal adhesion kinase (FAK) activation.

The result is increased collagen types I and III. MMP activity decreases while TIMP levels rise.

Together, these effects promote myocardial fibrosis.

Metabolic & Other Roles
Emerging research links kisspeptin to broader metabolic processes, including regulation of glucose homeostasis, feeding behavior, body composition, and cardiac function Frontiers.

Summary Table