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α-Phenylacetoacetonitrile (APAAN) is one of the most important pre-precursors for amphetamine production in recent years.
This assumption is based on seizure data but there is little analytical data available showing how much amphetamine really originated from APAAN.
In this study, several syntheses of amphetamine following the Leuckart route were performed starting from different organic compounds including APAAN.
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The organic phases were analysed using gas chromatography-mass spectrometry (GC-MS) to search for signals caused by possible APAAN markers.
Researchers discovered and isolated three compounds, and the syntheses showed they are highly specific for APAAN use.
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Thus, mass spectra, high-resolution MS, and NMR data characterized the compounds and identified them as 2-phenyl-2-butenenitrile, 3-amino-2-phenyl-2-butenenitrile, and 4-amino-6-methyl-5-phenylpyrimidine.
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Thus, researchers searched seized amphetamine data to determine the prevalence of illicitly produced amphetamine.
Researchers used data from more than 580 cases in amphetamine profiling databases in Germany and the Netherlands for this purpose.
Moreover, these databases allowed analysis of the yearly occurrence of the markers going back to 2009.
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The markers revealed a trend that was in agreement with seizure reports and reflected an increasing use of APAAN from 2010 on.
This paper presents experimental proof that APAAN is indeed the most important pre-precursor of amphetamine in recent years.
It also illustrates how important it is to look for new ways to identify current trends in drug production since such trends can change within a few years.
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